| data | ora | incontro | esito |
| 06/11/25 | 18:45 | Basilea – FCSB | goal ospite |
| 06/11/25 | 18:45 | Din. Zagabria – Celta Vigo | X2 |
| 06/11/25 | 18:45 | Malmo – Panathinaikos | X2 |
| 06/11/25 | 18:45 | Midtjylland – Celtic | goal |
| 06/11/25 | 18:45 | Nizza – Friburgo | 1X + 1/4 |
| 06/11/25 | 18:45 | Salzburg – Eagles | 1 |
| 06/11/25 | 18:45 | Stella Rossa – Lille | goal |
| 06/11/25 | 18:45 | Sturm Graz – Nottingham | goal casa |
| 06/11/25 | 18:45 | Utrecht – FC Porto | 2 |
| 06/11/25 | 21:00 | Aston Villa – Tel Aviv | 1 |
| 06/11/25 | 21:00 | Betis – Lione | 1X |
| 06/11/25 | 21:00 | Bologna – Brann | 1X + 1/4 |
| 06/11/25 | 21:00 | Braga – Genk | goal ospite |
| 06/11/25 | 21:00 | Ferencvaros – Ludogorets | 1X + OV 1,5 |
| 06/11/25 | 21:00 | Paok – Young Boys | 1X + OV 1,5 |
| 06/11/25 | 21:00 | Plzen – Fenerbhace | goal |
| 06/11/25 | 21:00 | Rangers – Roma | X2 + 1/4 |
| 06/11/25 | 21:00 | Stoccarda – Feyenoord | OV 0,5 primo tempo + OV 0,5 secondo tempo |